J.T. Brown scored all four goals for No. 1 Minnesota-Duluth, which beat Alaska-Anchorage 4-1 on Friday.
It was the second hat trick of the season for Brown, who scored three against Nebraska-Omaha on Jan. 13. He is the 12th Bulldogs player to score four goals in a game.
Travis Oleksuk posted four assists and Kenny Reiter made 17 saves for the Bulldogs (18-5-4, 12-4-3 WCHA).
Mitch Bruijsten scored a power-play goal for the Seawolves (6-17-2, 3-17-1).